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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of BAX mRNA; perfluorooctane sulfonic acid results in increased expression of BAX proteinPMID:24616003 PMID:26844784 PMID:35934180
Baxdecreases expressionISOBax (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of BAX mRNAPMID:23562911
Baxincreases expressionISOBax (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of BAX mRNA; perfluorooctane sulfonic acid results in increased expression of BAX proteinPMID:21115943 PMID:23562911 PMID:34303733 PMID:36988283
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of BAX mRNA; perfluorooctane sulfonic acid results in increased expression of BAX proteinPMID:22976841 PMID:26844784 PMID:32790152 PMID:34006824 PMID:36988283
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of BAX mRNA; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX protein]PMID:36331819 PMID:36988283
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[perfluorooctane sulfonic acid results in increased phosphorylation of and results in increased activity of MAPK8 protein] which affects the localization of BAX protein; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX protein]; MIR155 mRNA promotes the reaction [perfluorooctane sulfonic acid results in increased expression of BAX protein]; perfluorooctane sulfonic acid promotes the reaction [BAX protein binds to BAK1 protein]; perfluorooctane sulfonic acid promotes the reaction [BAX protein binds to PPID protein]PMID:26844784 PMID:34006824 PMID:36988283
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