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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationEXP 6480464CTDCadmium Chloride affects the localization of BAX proteinPMID:19523979
Baxincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of BAX mRNA; Cadmium Chloride results in increased expression of BAX proteinPMID:24492640 PMID:27389774 PMID:28110594 PMID:28390674 PMID:28457857 PMID:31433112 PMID:32392679 PMID:34662668
Baxmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; [Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; Fra a 1 allergen, Fragaria ananassa inhibits the reaction [Cadmium Chloride results in increased expression of BAX mRNA]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; zinc chloride affects the reaction [Cadmium Chloride results in increased expression of BAX protein]PMID:24492640 PMID:25031709 PMID:26396915 PMID:27389774 PMID:28110594 PMID:28390674 PMID:31433112 PMID:32392679 PMID:33031904 PMID:34558789 PMID:34767868 PMID:36718047
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDCadmium Chloride affects the expression of BAX mRNAPMID:23941782
Baxincreases expressionISOBax (Mus musculus)6480464CTDCadmium Chloride results in increased expression of BAX proteinPMID:21337715 PMID:23376140 PMID:25111876 PMID:29486218 PMID:30030080
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of BAX mRNA; Cadmium Chloride results in increased expression of BAX proteinPMID:12160620 PMID:22961094 PMID:23485651 PMID:25111876 PMID:25596134 PMID:28422390
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; Cholesterol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Quercetin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; TFE3 protein inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]PMID:21337715 PMID:29486218 PMID:30030080 PMID:33359024
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein]; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of BAX mRNA]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of BAX mRNA]; naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]PMID:11341981 PMID:23941782 PMID:28422390 PMID:37300854
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