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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of BAX mRNA; Diethylnitrosamine results in decreased expression of BAX proteinPMID:19931519 PMID:22393308 PMID:30423403 PMID:31129132 PMID:35437842
Baxincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of BAX proteinPMID:19073162 PMID:21167192
Baxmultiple interactionsEXP 6480464CTD[2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of BAX protein; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; [Diethylnitrosamine co-treated with Cyclohexanols] results in decreased expression of BAX protein; [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BAX mRNA; chrysin promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; morin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]; neferine inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; neferine inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]; Plant Oils inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; Plant Oils inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]; Resveratrol promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; zerumbone promotes the reaction [[2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of BAX protein]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]PMID:11915028 PMID:17393424 PMID:19073162 PMID:19931519 PMID:20452335 PMID:21167192 PMID:21554863 PMID:22393308 PMID:23830814 PMID:30423403 PMID:31129132 PMID:35437842
Baxdecreases expressionISOBax (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of BAX proteinPMID:34726822
Baxincreases expressionISOBax (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of BAX mRNA; Diethylnitrosamine results in increased expression of BAX proteinPMID:18056438 PMID:19100860 PMID:21607683 PMID:26464624 PMID:27553677
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCYP2E1 protein promotes the reaction [Diethylnitrosamine results in increased expression of BAX mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]PMID:18056438 PMID:34726822
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