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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTD4-nonylphenol results in increased expression of BAX mRNA; 4-nonylphenol results in increased expression of BAX proteinPMID:26804764 PMID:27087316 PMID:27109770 PMID:30228064
Baxmultiple interactionsEXP 6480464CTD3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]PMID:26804764
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTD4-nonylphenol results in decreased expression of BAX mRNA; 4-nonylphenol results in decreased expression of BAX proteinPMID:15461258 PMID:26804032
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