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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDbisphenol A results in increased expression of BAX; bisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX proteinPMID:23146694 PMID:23328667 PMID:24768697 PMID:25181051 PMID:25381574 PMID:25461564 PMID:25963729 PMID:27189055 PMID:27296223 PMID:27539358 PMID:30228064 PMID:32145629 PMID:32153214 PMID:32714078 PMID:34947998 PMID:35465754 PMID:35699857 PMID:35887390 PMID:35890622 PMID:38006930
Baxmultiple interactionsEXP 6480464CTD18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of BAX]; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of BAX mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; Lycopene inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]PMID:25963729 PMID:27189055 PMID:32153214 PMID:35465754 PMID:35699857 PMID:36041667
Baxaffects expressionISOBax (Mus musculus)6480464CTDbisphenol A affects the expression of BAX proteinPMID:33509759
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDbisphenol A affects the expression of BAX mRNA; bisphenol A affects the expression of BAX proteinPMID:24156707 PMID:31916403
Baxdecreases expressionISOBax (Mus musculus)6480464CTDbisphenol A results in decreased expression of BAX mRNAPMID:29741722
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDbisphenol A results in decreased expression of BAX mRNA; bisphenol A results in decreased expression of BAX proteinPMID:15461258 PMID:21277958 PMID:23222814 PMID:24901218
Baxincreases activityISOBax (Mus musculus)6480464CTDbisphenol A results in increased activity of BAX proteinPMID:33485121
Baxincreases expressionISOBax (Mus musculus)6480464CTDbisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX proteinPMID:11906184 PMID:22269103 PMID:24458533 PMID:24905940 PMID:26512966 PMID:26746108 PMID:28393075 PMID:31201698 PMID:31263496 PMID:32407858 PMID:32488702 PMID:33485121 PMID:34186417 PMID:35219798 PMID:36858637
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDbisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX proteinPMID:30036487 PMID:33039870 PMID:34186270 PMID:34664771 PMID:35439536 PMID:37143426
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in increased activity of BAX protein]; [Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in increased activity of BAX protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Ginsenosides inhibits the reaction [bisphenol A results in increased expression of BAX protein]; KN 62 inhibits the reaction [bisphenol A results in increased expression of BAX protein]; U 0126 inhibits the reaction [bisphenol A results in increased expression of BAX protein]; VDAC1 promotes the reaction [bisphenol A results in increased expression of BAX protein]; W 7 inhibits the reaction [bisphenol A results in increased expression of BAX protein]PMID:22269103 PMID:24905940 PMID:26512966 PMID:31756439 PMID:32488702 PMID:33485121 PMID:34186417 PMID:36858637
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[bisphenol A co-treated with 4-cumylphenol] results in decreased expression of BAX mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BAX mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BAX mRNA; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of BAX protein]PMID:23222814 PMID:28628672 PMID:31916403 PMID:35439536 PMID:36235125
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