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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:31746
Term: kainic acid
Definition: A pyrrolidinecarboxylic acid that has formula C10H15NO4.
Chemical ID: MESH:D007608
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDKainic Acid results in increased expression of BAX mRNA; Kainic Acid results in increased expression of BAX proteinPMID:18711747 PMID:19700661 PMID:31430510
Baxmultiple interactionsEXP 6480464CTDoridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA]PMID:31430510
Baxincreases expressionISOBax (Mus musculus)6480464CTDKainic Acid results in increased expression of BAX proteinPMID:25453207
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDValproic Acid inhibits the reaction [Kainic Acid results in increased expression of BAX protein]PMID:25453207
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDEPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]PMID:18711747
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