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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:30614
Term: benzo[a]pyrene diol epoxide I
Definition: An epoxide that has formula C20H14O3.
Chemical ID: MESH:D015123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein affects the susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidePMID:21983885
Baxincreases expressionISOBAX (Homo sapiens)6480464CTD7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BAX mRNAPMID:17944540 PMID:26238291 PMID:28593498
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDBAX protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]; BAX protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP7 protein]PMID:21983885
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