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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDCopper results in increased expression of BAX proteinPMID:30556269
Baxmultiple interactionsEXP 6480464CTD[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein]PMID:22085843 PMID:32881150 PMID:34577062
Baxincreases expressionISOBax (Mus musculus)6480464CTDCopper analog results in increased expression of BAX protein; Copper results in increased expression of BAX proteinPMID:22000994 PMID:34676557
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCopper results in increased expression of BAX mRNA; Copper results in increased expression of BAX proteinPMID:15880691 PMID:16962711
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX proteinPMID:31491480
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in decreased expression of BAX mRNA; [Copper co-treated with Disulfiram] results in increased expression of BAX protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]PMID:23033007 PMID:29115570 PMID:30911355
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