Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDarsenite results in increased expression of BAX proteinPMID:29324385
Baxmultiple interactionsEXP 6480464CTDSelenium inhibits the reaction [arsenite results in increased expression of BAX protein]PMID:29324385
Baxdecreases expressionISOBax (Mus musculus)6480464CTDarsenite results in decreased expression of BAX mRNAPMID:18929588
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDarsenite results in decreased expression of BAX proteinPMID:32406909
Baxincreases activityISOBAX (Homo sapiens)6480464CTDarsenite results in increased activity of BAX proteinPMID:17553788
Baxincreases expressionISOBax (Mus musculus)6480464CTDarsenite results in increased expression of BAX proteinPMID:32443253
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDarsenite results in increased expression of BAX mRNA; arsenite results in increased expression of BAX proteinPMID:20083129 PMID:26677073
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCALR protein affects the reaction [arsenite results in increased expression of BAX protein]; TRP53 protein affects the reaction [arsenite results in decreased expression of BAX mRNA]PMID:18929588 PMID:32443253
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDarsenite promotes the reaction [G3BP1 protein binds to BAX mRNA]; G3BP1 protein affects the reaction [arsenite results in decreased expression of BAX protein]; Heparin inhibits the reaction [arsenite results in increased expression of BAX protein]; Thapsigargin promotes the reaction [arsenite results in increased expression of BAX protein]PMID:26677073 PMID:32406909
Go Back to source page   Continue to Ontology report