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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of BAX mRNA; Benzo(a)pyrene results in increased expression of BAX proteinPMID:23510837 PMID:31568845 PMID:34027802
Baxmultiple interactionsEXP 6480464CTDCatechin analog inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]PMID:31568845 PMID:34027802
Baxaffects methylationISOBAX (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of BAX promoterPMID:27901495
Baxdecreases expressionISOBax (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of BAX proteinPMID:28681665
Baxincreases expressionISOBax (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of BAX mRNA; Benzo(a)pyrene results in increased expression of BAX proteinPMID:21569818 PMID:21964900 PMID:22228805 PMID:22610609 PMID:23747951 PMID:27208085 PMID:28032951 PMID:30520250 PMID:32061149 PMID:36193556
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of BAX mRNA; Benzo(a)pyrene results in increased expression of BAX proteinPMID:10837373 PMID:11782367 PMID:15735009 PMID:16041517 PMID:16120219 PMID:20106945 PMID:21632981 PMID:21714911 PMID:26238291 PMID:30562542 PMID:30659931 PMID:32234424
Baxincreases methylationISOBAX (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of BAX 3' UTRPMID:27901495
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of BAX mRNA; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]PMID:27858113 PMID:28032951 PMID:28681665 PMID:30520250 PMID:32061149 PMID:36193556
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in decreased expression of BAX protein; [Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of BAX mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of BAX mRNA; [Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of BAX mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA]; Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; TP53 affects the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]PMID:10837373 PMID:16041517 PMID:17690111 PMID:21882252 PMID:24289642 PMID:32802178
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