GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of BAX mRNA; Benzo(a)pyrene results in increased expression of BAX protein | PMID:23510837 PMID:31568845 PMID:34027802 | Bax | multiple interactions | EXP | | 6480464 | CTD | Catechin analog inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] | PMID:31568845 PMID:34027802 | Bax | affects methylation | ISO | BAX (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of BAX promoter | PMID:27901495 | Bax | decreases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of BAX protein | PMID:28681665 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of BAX mRNA; Benzo(a)pyrene results in increased expression of BAX protein | PMID:21569818 PMID:21964900 PMID:22228805 PMID:22610609 PMID:23747951 PMID:27208085 PMID:28032951 PMID:30520250 PMID:32061149 PMID:36193556 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of BAX mRNA; Benzo(a)pyrene results in increased expression of BAX protein | PMID:10837373 PMID:11782367 PMID:15735009 PMID:16041517 PMID:16120219 PMID:20106945 PMID:21632981 PMID:21714911 PMID:26238291 PMID:30562542 PMID:30659931 PMID:32234424 | Bax | increases methylation | ISO | BAX (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of BAX 3' UTR | PMID:27901495 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of BAX mRNA; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] | PMID:27858113 PMID:28032951 PMID:28681665 PMID:30520250 PMID:32061149 PMID:36193556 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in decreased expression of BAX protein; [Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of BAX mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of BAX mRNA; [Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of BAX mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA]; Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; TP53 affects the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA] | PMID:10837373 PMID:16041517 PMID:17690111 PMID:21882252 PMID:24289642 PMID:32802178 | |
Go Back to source page | Continue to Ontology report |