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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of BAX mRNA; sodium arsenite results in increased expression of BAX proteinPMID:14514659 PMID:19616567 PMID:20830294 PMID:24497207 PMID:24517892 PMID:24952339 PMID:25179238 PMID:26767369 PMID:27425645 PMID:27966075 PMID:29497947 PMID:30408888 PMID:30558456 PMID:31163222 PMID:35259467 PMID:35939230
Baxmultiple interactionsEXP 6480464CTD[SERPINF1 protein co-treated with sodium arsenite] results in increased expression of BAX protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in increased expression of BAX protein]]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Galactose promotes the reaction [sodium arsenite results in increased expression of BAX mRNA]; p-coumaric acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; Polysaccharides inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; Polysaccharides inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; sodium arsenite inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; Succimer inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; Taurine inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; Taurine inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein]PMID:12690470 PMID:14514659 PMID:19616567 PMID:20830294 PMID:24497207 PMID:24952339 PMID:26396915 PMID:27966075 PMID:30408888 PMID:30558456 PMID:30835071 PMID:31163222 PMID:32402895 PMID:35259467 PMID:36822304
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDsodium arsenite affects the expression of BAX proteinPMID:36958258
Baxaffects localizationISOBax (Mus musculus)6480464CTDsodium arsenite affects the localization of BAX proteinPMID:16166651
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDsodium arsenite affects the localization of BAX proteinPMID:17849503
Baxdecreases expressionISOBax (Mus musculus)6480464CTDsodium arsenite results in decreased expression of BAX mRNAPMID:17558810 PMID:19822182
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of BAX mRNA; sodium arsenite results in decreased expression of BAX proteinPMID:12760830 PMID:21776218 PMID:32890875 PMID:33261869
Baxincreases cleavageISOBAX (Homo sapiens)6480464CTDsodium arsenite results in increased cleavage of BAX proteinPMID:34861471
Baxincreases expressionISOBax (Mus musculus)6480464CTDsodium arsenite results in increased expression of BAX mRNA; sodium arsenite results in increased expression of BAX proteinPMID:11035063 PMID:20336670 PMID:21134390 PMID:21642427 PMID:27723467 PMID:28757890 PMID:29854073 PMID:30278210 PMID:33242462 PMID:33497687
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDsodium arsenite results in increased expression of BAX mRNA; sodium arsenite results in increased expression of BAX proteinPMID:19615344 PMID:20339138 PMID:21642427 PMID:26404762 PMID:26878773 PMID:28512695 PMID:28586017 PMID:28595984 PMID:29039521 PMID:29864498 PMID:30460075 PMID:30738023 PMID:31139082 PMID:35142421
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of BAX mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; [Sulfur Dioxide co-treated with sodium arsenite] results in increased expression of BAX mRNA; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; Drugs, Chinese Herbal inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; EGR1 gene mutant form inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; salvin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; TRP53 protein promotes the reaction [Plant Extracts inhibits the reaction [sodium arsenite results in increased expression of BAX protein]]PMID:21642427 PMID:27723467 PMID:28757890 PMID:29854073 PMID:30195209 PMID:33242462 PMID:33497687 PMID:35714946
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in decreased expression of BAX protein; BNIP3L protein affects the reaction [sodium arsenite results in increased cleavage of BAX protein]; calpeptin inhibits the reaction [sodium arsenite results in increased cleavage of BAX protein]; daphnetin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; ELK1 mutant form inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Lapatinib inhibits the reaction [sodium arsenite results in decreased expression of BAX protein]; Lithium inhibits the reaction [sodium arsenite affects the localization of BAX protein]; Lithium inhibits the reaction [sodium arsenite promotes the reaction [BAX protein binds to BAX protein]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of BAX protein]; pterostilbene inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased cleavage of BAX protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in decreased expression of BAX protein]]; SB 216763 inhibits the reaction [sodium arsenite affects the localization of BAX protein]; SB 216763 inhibits the reaction [sodium arsenite promotes the reaction [BAX protein binds to BAX protein]]; sodium arsenite promotes the reaction [BAX protein binds to BAX protein]; SQSTM1 protein affects the reaction [sodium arsenite results in increased cleavage of BAX protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of BAX mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of BAX protein]PMID:17849503 PMID:19615344 PMID:21642427 PMID:26404762 PMID:26878773 PMID:30738023 PMID:31139082 PMID:32802178 PMID:32890875 PMID:33261869 PMID:34861471 PMID:35142421
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