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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsISOBAX (Homo sapiens)127284846RGDN-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases expression of BAX protein in the stomach) 
Baxincreases expressionEXP 6480464CTDAcetylcysteine results in increased expression of BAX mRNAPMID:26332274
Baxmultiple interactionsEXP 6480464CTDAcetylcysteine affects the reaction [lead acetate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Glyphosate results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased expression of BAX mRNA]PMID:18547707 PMID:22085843 PMID:25845326 PMID:26797587 PMID:26804764 PMID:27189055 PMID:29087013 PMID:30104959 PMID:31173782 PMID:32402895 PMID:33031904 PMID:33797725
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDAcetylcysteine results in decreased expression of BAX proteinPMID:19376147
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDAcetylcysteine results in increased expression of BAX proteinPMID:11166918
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]PMID:21533816 PMID:21549813 PMID:21616140 PMID:26512966 PMID:29248572 PMID:31368586 PMID:33485121 PMID:34547296 PMID:37308051
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of BAX protein]; Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenbendazole analog results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenbendazole results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [glabridin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of BAX protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased expression of BAX protein]PMID:11341981 PMID:15496615 PMID:15735709 PMID:16169029 PMID:17237268 PMID:17542780 PMID:17574045 PMID:18034189 PMID:18412143 PMID:19376147 PMID:19954742 PMID:20674558 PMID:20981856 PMID:21310227 PMID:22245127 PMID:22704995 PMID:23711929 PMID:24036456 PMID:25034532 PMID:26772155 PMID:27816613 PMID:28804952 PMID:29945211 PMID:30769050 PMID:30797898 PMID:30917517 PMID:31313457 PMID:32527420 PMID:32540572 PMID:33971260 PMID:35430258 PMID:35569513 PMID:36029289 PMID:36070022 PMID:37084995 PMID:37148176
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