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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDFructose results in increased expression of BAX proteinPMID:33475235
Baxmultiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [Fructose results in increased expression of BAX protein]PMID:33475235
Baxincreases expressionISOBax (Mus musculus)6480464CTDFructose results in increased expression of BAX proteinPMID:27531227
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of BAX protein; [Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA; [Fructose co-treated with Dietary Fats] results in increased expression of BAX protein; Plant Preparations inhibits the reaction [Fructose results in increased expression of BAX protein]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX mRNA]; troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of BAX protein]PMID:27531227 PMID:28916335 PMID:37271273
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