GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | affects expression | EXP | | 6480464 | CTD | Rotenone affects the expression of BAX protein | PMID:25423838 | Bax | increases expression | EXP | | 6480464 | CTD | Rotenone results in increased expression of BAX mRNA; Rotenone results in increased expression of BAX protein | PMID:18082360 PMID:21807080 PMID:25263579 PMID:25502462 PMID:27180985 PMID:29174113 PMID:33823232 PMID:35104487 PMID:35253580 | Bax | multiple interactions | EXP | | 6480464 | CTD | [3-bromo-2-oxopropionic acid co-treated with Rotenone] results in increased expression of BAX protein; Antiparkinson Agents inhibits the reaction [Rotenone results in decreased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]; Bibenzyls inhibits the reaction [Rotenone results in increased expression of BAX protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]]; GHRL protein inhibits the reaction [Rotenone results in increased expression of BAX protein]; GHSR protein affects the reaction [GHRL protein inhibits the reaction [Rotenone results in increased expression of BAX protein]]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Rotenone results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of BAX mRNA]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein] | PMID:21807080 PMID:25263579 PMID:25423838 PMID:25502462 PMID:27180985 PMID:29174113 PMID:31585160 PMID:35104487 | Bax | affects expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Rotenone affects the expression of BAX protein | PMID:24755484 | Bax | increases activity | ISO | Bax (Mus musculus) | 6480464 | CTD | Rotenone results in increased activity of BAX protein | PMID:21216964 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Rotenone results in increased expression of BAX; Rotenone results in increased expression of BAX mRNA; Rotenone results in increased expression of BAX protein | PMID:17702527 PMID:25481089 PMID:26031332 PMID:35919817 PMID:36774383 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Rotenone results in increased expression of BAX mRNA; Rotenone results in increased expression of BAX protein | PMID:19539006 PMID:19723537 PMID:19777565 PMID:23963993 PMID:25263579 PMID:25991017 PMID:26276080 PMID:29886133 PMID:33512557 PMID:34182063 PMID:36446982 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | CASP2 protein affects the reaction [Rotenone results in increased activity of BAX protein]; oleuropein inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein] | PMID:21216964 PMID:26031332 PMID:36774383 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | ALDH2 protein inhibits the reaction [Rotenone results in increased expression of BAX protein]; baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein]; FBXO22 protein inhibits the reaction [Rotenone results in increased expression of BAX protein]; GAPDH protein polymorphism promotes the reaction [Rotenone results in increased expression of BAX protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Rotenone results in increased expression of BAX protein]; PHLPP1 protein inhibits the reaction [FBXO22 protein inhibits the reaction [Rotenone results in increased expression of BAX protein]]; PQQ Cofactor inhibits the reaction [Rotenone affects the expression of BAX protein]; PQQ Cofactor inhibits the reaction [Rotenone results in increased expression of BAX protein]; Ranitidine inhibits the reaction [Rotenone results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Rotenone results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Rotenone results in increased expression of BAX protein]; Tranexamic Acid inhibits the reaction [Rotenone results in increased expression of BAX protein] | PMID:19539006 PMID:19723537 PMID:24755484 PMID:25263579 PMID:25991017 PMID:26276080 PMID:29886133 PMID:34182063 PMID:36446982 | |
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