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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28112
Term: nickel atom
Definition: Chemical element (nickel group element atom) with atomic number 28.
Chemical ID: MESH:D009532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDNickel analog results in increased expression of BAX protein; Nickel results in increased expression of BAX proteinPMID:21417627 PMID:27257140
Baxmultiple interactionsEXP 6480464CTDGrape Seed Proanthocyanidins inhibits the reaction [Nickel results in increased expression of BAX protein]PMID:21417627
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDNickel analog affects the expression of BAX proteinPMID:23776134
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDNickel results in increased expression of BAX mRNAPMID:24768652 PMID:25583101
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[cobalt ferrite binds to Nickel] which results in increased expression of BAX protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]; Nickel results in increased expression of and results in increased cleavage of BAX protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein]PMID:29115570 PMID:31943712 PMID:31953414 PMID:36073959
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