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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDResveratrol results in decreased expression of BAX; Resveratrol results in decreased expression of BAX mRNA; Resveratrol results in decreased expression of BAX proteinPMID:21111721 PMID:23284668 PMID:23353162 PMID:33775663
Baxincreases expressionEXP 6480464CTDresveratrol results in increased expression of BAX proteinPMID:23747682
Baxmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; [Resveratrol co-treated with Propofol] results in decreased expression of BAX; [Resveratrol co-treated with Testosterone] results in increased expression of BAX protein; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; Resveratrol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]; Resveratrol inhibits the reaction [MIR136 promotes the reaction [Paraquat results in increased expression of BAX protein]]; Resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Oxidopamine results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Paraquat results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of BAX]; Resveratrol promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]PMID:19073162 PMID:19466539 PMID:23353162 PMID:23833438 PMID:24492640 PMID:25191525 PMID:25714330 PMID:26054749 PMID:28713934 PMID:31433112 PMID:33587916 PMID:34302886 PMID:35024197 PMID:35236239
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDresveratrol affects the expression of BAX mRNAPMID:16624241
Baxaffects foldingISOBAX (Homo sapiens)6480464CTDresveratrol affects the folding of BAX proteinPMID:16617056
Baxaffects localizationISOBax (Mus musculus)6480464CTDresveratrol affects the localization of BAX proteinPMID:20940732
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDresveratrol affects the localization of BAX proteinPMID:15827328 PMID:16617056
Baxdecreases expressionISOBax (Mus musculus)6480464CTDresveratrol results in decreased expression of BAX mRNA; resveratrol results in decreased expression of BAX proteinPMID:18819863 PMID:23090186 PMID:25116358
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDresveratrol results in decreased expression of BAX mRNA; resveratrol results in decreased expression of BAX proteinPMID:14749477 PMID:16998810 PMID:21505870
Baxincreases activityISOBAX (Homo sapiens)6480464CTDresveratrol results in increased activity of BAX proteinPMID:22644961
Baxincreases expressionISOBax (Mus musculus)6480464CTDResveratrol results in increased expression of BAX mRNA; Resveratrol results in increased expression of BAX proteinPMID:15637762 PMID:25505154
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDResveratrol analog results in increased expression of BAX protein; Resveratrol results in increased expression of BAX; Resveratrol results in increased expression of BAX mRNA; Resveratrol results in increased expression of BAX proteinPMID:12632486 PMID:15633232 PMID:15827328 PMID:16731767 PMID:17049120 PMID:17164350 PMID:17823925 PMID:17868649 PMID:19796711 PMID:19846903 PMID:20717957 PMID:21209944 PMID:21743969 PMID:23152798 PMID:23536519 PMID:24331535 PMID:24604347 PMID:25776512 PMID:26911335 PMID:26969377 PMID:29705353 PMID:31151226
Baxincreases localizationISOBAX (Homo sapiens)6480464CTDresveratrol results in increased localization of BAX proteinPMID:19423619
Baxincreases response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to resveratrolPMID:16518869 PMID:16550006
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin affects the localization of BAX protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Cisplatin affects the localization of BAX protein]; Resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Resveratrol inhibits the reaction [ERCC6 gene mutant form results in increased expression of BAX protein]; Resveratrol inhibits the reaction [glyoxylic acid results in increased expression of BAX protein]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]PMID:21593185 PMID:22763982 PMID:24040102 PMID:24682241 PMID:25440059 PMID:25665036 PMID:26450947 PMID:34333021
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[allyl sulfide co-treated with Resveratrol] results in increased expression of BAX mRNA; [benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Resveratrol results in increased localization of BAX protein]; [Doxorubicin co-treated with Resveratrol] results in increased expression of BAX mRNA; [Doxorubicin co-treated with Resveratrol] results in increased expression of BAX protein; [Plant Extracts co-treated with Resveratrol] results in decreased expression of BAX mRNA; [Raloxifene Hydrochloride co-treated with Resveratrol] results in increased expression of BAX mRNA; [Resveratrol co-treated with TNFSF10 protein] results in increased activity of BAX protein; [Resveratrol results in decreased expression of MTA1 protein] which results in increased expression of BAX protein; [Resveratrol results in increased acetylation of and results in increased activity of TP53 protein] promotes the reaction [TP53 protein binds to BAX promoter]; [Resveratrol results in increased phosphorylation of TP53 protein] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; BAX protein promotes the reaction [Resveratrol promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Resveratrol results in increased localization of BAX protein]; CASP2 protein affects the reaction [Resveratrol affects the folding of BAX protein]; CTSD protein affects the reaction [Resveratrol promotes the reaction [BAX protein binds to BAX protein]]; MRK 003 affects the reaction [Resveratrol results in increased expression of BAX]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein]; Resveratrol inhibits the reaction [cudraflavone B results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Ethanol results in increased expression of BAX protein]; Resveratrol inhibits the reaction [GBA1 protein mutant form results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]; Resveratrol inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Rotenone results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Rotenone results in increased expression of BAX protein]; Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Resveratrol promotes the reaction [BAX protein binds to BAX protein]; Resveratrol results in increased expression of and affects the localization of BAX protein; Resveratrol results in increased expression of and results in increased localization of BAX protein; SB 203580 promotes the reaction [Resveratrol results in increased activity of BAX protein]; TP53 affects the reaction [Resveratrol results in increased expression of BAX protein]PMID:12902349 PMID:16518869 PMID:16617056 PMID:17116725 PMID:17636462 PMID:18222423 PMID:18512326 PMID:19810103 PMID:19846903 PMID:20097879 PMID:21505870 PMID:21743969 PMID:22644961 PMID:23557933 PMID:23881456 PMID:24218232 PMID:24224909 PMID:25991017 PMID:26027833 PMID:26772155 PMID:26969377 PMID:29705353 PMID:31943712
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