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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNA]PMID:21281706
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDDactinomycin results in increased expression of BAX mRNA; Dactinomycin results in increased expression of BAX proteinPMID:10760829 PMID:12927789 PMID:21527772
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDDactinomycin promotes the reaction [BAX protein binds to BAX protein]PMID:26670606
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDMorphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]PMID:12927789
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