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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:27504
Term: mitomycin C
Definition: A mitomycin that has formula C15H18N4O5.
Chemical ID: MESH:D016685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDMitomycin affects the localization of BAX proteinPMID:19834285
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDMitomycin results in decreased expression of BAX mRNAPMID:19757172
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDMitomycin results in increased expression of BAX mRNA; Mitomycin results in increased expression of BAX proteinPMID:11867586 PMID:15120327 PMID:18615204
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDsilybin inhibits the reaction [Mitomycin affects the localization of BAX protein]; Tamoxifen promotes the reaction [Mitomycin results in decreased expression of BAX mRNA]PMID:19757172 PMID:19834285
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