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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA; 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX proteinPMID:30101532 PMID:34896434
Baxincreases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of BAX mRNAPMID:24269759
Baxmultiple interactionsEXP 6480464CTD[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]; Taurine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]; Taurine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]PMID:30101532 PMID:34896434
Baxdecreases expressionISOBax (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA; 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX proteinPMID:25478867 PMID:33347706
Baxincreases expressionISOBAX (Homo sapiens)6480464CTD9,10-Dimethyl-1,2-benzanthracene metabolite results in increased expression of BAX mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of BAX mRNAPMID:20562217
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BAX protein; [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]; [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]; [Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of BAX protein; beta-elemene inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BAX protein]; Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]; Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of BAX protein]; Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]; Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]; Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]; Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]PMID:22760862 PMID:25478867 PMID:32662567 PMID:33347706
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in increased expression of BAX mRNA]PMID:20562217
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