Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDCadmium results in decreased expression of BAX proteinPMID:23741317
Baxincreases expressionEXP 6480464CTDCadmium results in increased expression of BAX mRNA; Cadmium results in increased expression of BAX proteinPMID:20455018 PMID:23577223 PMID:25388156 PMID:25808797 PMID:37342552 PMID:37949422
Baxmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; [cadmium nitrate results in increased abundance of Cadmium] which results in increased expression of BAX mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; bergenin inhibits the reaction [Cadmium results in increased expression of BAX protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; Lithium inhibits the reaction [Cadmium results in increased expression of BAX protein]; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]PMID:20455018 PMID:28413886 PMID:33031904 PMID:34558789 PMID:34767868 PMID:36718047 PMID:37342552 PMID:37949422
Baxdecreases expressionISOBax (Mus musculus)6480464CTDCadmium results in decreased expression of BAX proteinPMID:22356713
Baxincreases cleavageISOBax (Mus musculus)6480464CTDCadmium results in increased cleavage of BAX proteinPMID:29982767
Baxincreases expressionISOBax (Mus musculus)6480464CTDCadmium results in increased expression of BAX mRNAPMID:26187450
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCadmium results in increased expression of BAX mRNAPMID:15016657 PMID:27687512 PMID:28507149
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; MT2A protein inhibits the reaction [Cadmium results in increased cleavage of BAX protein]PMID:29982767 PMID:33359024
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]; MT2A protein inhibits the reaction [Cadmium results in increased expression of BAX mRNA]; NR4A1 mutant form inhibits the reaction [Cadmium results in increased expression of BAX mRNA]PMID:15016657 PMID:28507149 PMID:29115570 PMID:37300854
Go Back to source page   Continue to Ontology report