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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationEXP 6480464CTDNicotine affects the localization of BAX proteinPMID:18203686
Baxdecreases expressionEXP 6480464CTDNicotine results in decreased expression of BAX proteinPMID:34153408
Baxincreases expressionEXP 6480464CTDNicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX proteinPMID:20339300 PMID:29972271
Baxmultiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]PMID:29972271
Baxdecreases expressionISOBax (Mus musculus)6480464CTDNicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX proteinPMID:17135361 PMID:31783125
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDNicotine results in decreased expression of BAX proteinPMID:20061081 PMID:20106947 PMID:30259641
Baxincreases expressionISOBax (Mus musculus)6480464CTDNicotine results in increased expression of BAX mRNAPMID:15831280
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDNicotine results in increased expression of BAX proteinPMID:33010382
Baxincreases phosphorylationISOBAX (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of BAX proteinPMID:17525161
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]PMID:17525161 PMID:18676776 PMID:20061081 PMID:30259641 PMID:33010382
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