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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTD2-Acetylaminofluorene results in increased expression of BAX mRNAPMID:17070881 PMID:19167416 PMID:22584684
Baxmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]PMID:11915028
Baxincreases expressionISOBax (Mus musculus)6480464CTD2-Acetylaminofluorene results in increased expression of BAX mRNAPMID:17317680 PMID:21607683
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDTRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]PMID:17317680
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