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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDMorphine results in decreased expression of BAX mRNAPMID:15183518
Baxincreases expressionEXP 6480464CTDMorphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX proteinPMID:12196588 PMID:18976035
Baxmultiple interactionsEXP 6480464CTDLithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]PMID:18976035
Baxincreases expressionISOBax (Mus musculus)6480464CTDMorphine results in increased expression of BAX proteinPMID:10809959
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDMorphine results in increased expression of BAX proteinPMID:10534122 PMID:19070643 PMID:21483469
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDTGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]PMID:10809959
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]PMID:10534122 PMID:12702572 PMID:12927789 PMID:17542780 PMID:21483469
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