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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDProgesterone results in decreased expression of BAX mRNAPMID:15941375
Baxmultiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased expression of BAX protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of BAX mRNAPMID:20732338 PMID:22465879
Baxincreases expressionISOBax (Mus musculus)6480464CTDProgesterone results in increased expression of BAX proteinPMID:21882229
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCALB1 protein inhibits the reaction [Progesterone results in increased expression of BAX protein]; S100G protein inhibits the reaction [Progesterone results in increased expression of BAX protein]PMID:21882229
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