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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNAPMID:21281706 PMID:21384494 PMID:25410718
Baxmultiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNA]PMID:21281706
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNA; Dichlorodiphenyl Dichloroethylene results in increased expression of BAX proteinPMID:19545618
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