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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of BAX proteinPMID:15964511
Baxincreases expressionEXP 6480464CTDEstradiol results in increased expression of BAX mRNAPMID:32145629
Baxmultiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased expression of BAX protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAX mRNA; Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased expression of BAX protein]]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]]PMID:20732338 PMID:22465879 PMID:29625166
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDEstradiol affects the expression of BAX mRNAPMID:11896290
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDEstradiol results in decreased expression of BAX mRNA; Estradiol results in decreased expression of BAX proteinPMID:15870704 PMID:18174961 PMID:31016752 PMID:33484789 PMID:34724321
Baxincreases expressionISOBax (Mus musculus)6480464CTDEstradiol results in increased expression of BAX proteinPMID:21882229
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDEstradiol analog results in increased expression of BAX mRNA; Estradiol analog results in increased expression of BAX protein; Estradiol results in increased expression of BAX mRNAPMID:20106945 PMID:24481588 PMID:36460128
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDEstradiol inhibits the reaction [manganese chloride results in increased expression of BAX protein]PMID:29183790
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Estradiol results in decreased expression of BAX protein]; [Fulvestrant co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] inhibits the reaction [Estradiol results in decreased expression of BAX protein]; allyl sulfide inhibits the reaction [Estradiol results in decreased expression of BAX protein]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of BAX protein]; Estradiol inhibits the reaction [APP protein results in increased expression of BAX protein]; Estradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]; RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of BAX protein]]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [APP protein results in increased expression of BAX protein]]PMID:15870704 PMID:18174961 PMID:33484789 PMID:34318539 PMID:34724321
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