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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDLipopolysaccharides affects the expression of BAX mRNAPMID:21127968
Baxincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of BAX proteinPMID:24973090 PMID:25557508 PMID:31486215 PMID:33677747 PMID:34859534 PMID:35110471
Baxmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; [Galactosamine co-treated with Lipopolysaccharides] results in increased expression of BAX mRNA; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; Sialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; SREBF2 protein affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]PMID:21401295 PMID:24973090 PMID:25557508 PMID:31486215 PMID:33677747 PMID:34859534 PMID:35110471
Baxaffects expressionISOBax (Mus musculus)6480464CTDLipopolysaccharides affects the expression of BAX proteinPMID:30261164
Baxincreases expressionISOBax (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of BAX mRNA; Lipopolysaccharides results in increased expression of BAX proteinPMID:21299906 PMID:24561306 PMID:27339419 PMID:27523796 PMID:30776389 PMID:32687258 PMID:36056792
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of BAX proteinPMID:11805214 PMID:16822680 PMID:23063943 PMID:33677747 PMID:34687491 PMID:35331853 PMID:36052886 PMID:37209277
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; [Galactosamine co-treated with Lipopolysaccharides] results in increased expression of BAX protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form]; Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Cyclosporine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; EPO protein inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of BAX protein]; Lipopolysaccharides inhibits the reaction [Indirubin E804 results in increased expression of BAX mRNA]; palmatine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Scutellaria baicalensis extract inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; sesamol affects the reaction [Lipopolysaccharides affects the expression of BAX protein]; Silymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]; zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]PMID:10205001 PMID:20558151 PMID:20850421 PMID:21299906 PMID:23107598 PMID:24561306 PMID:27523796 PMID:30261164 PMID:30776389 PMID:32687258 PMID:36056792 PMID:36169195
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDadenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Bucladesine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; alpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Bucladesine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; HIPK1 protein inhibits the reaction [MIR335 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; KR-31612 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Lipopolysaccharides promotes the reaction [SREBF2 protein binds to BAX promoter]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; MIR335 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; NEAT1 affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; SREBF2 protein affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; TLR4 protein inhibits the reaction [NEAT1 affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; UBE2I protein inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; ZNF644 mRNA alternative form inhibits the reaction [MIR335 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; ZNF644 mRNA alternative form promotes the reaction [Lipopolysaccharides results in increased expression of BAX protein]PMID:11805214 PMID:16822680 PMID:23063943 PMID:33677747 PMID:34687491 PMID:36052886 PMID:37209277
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