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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16348
Term: 3-nitropropanoic acid
Definition: A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Chemical ID: MESH:C015392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationEXP 6480464CTD3-nitropropionic acid affects the localization of BAX proteinPMID:11080188
Baxincreases expressionEXP 6480464CTD3-nitropropionic acid results in increased expression of BAX mRNAPMID:21827809 PMID:21945202
Baxmultiple interactionsEXP 6480464CTD[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BAX protein; Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; ursodoxicoltaurine inhibits the reaction [3-nitropropionic acid affects the localization of BAX protein]PMID:11080188 PMID:15571979 PMID:21827809 PMID:21945202
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