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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDQuercetin results in decreased expression of BAX mRNAPMID:23281070
Baxincreases expressionEXP 6480464CTDQuercetin analog results in increased expression of BAX proteinPMID:23907460
Baxmultiple interactionsEXP 6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Quercetin analog results in increased expression of BAX protein]; Quercetin affects the reaction [Glucose affects the expression of BAX protein]; Quercetin analog inhibits the reaction [AGT protein results in increased expression of BAX protein]; Quercetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein]; Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; Quercetin inhibits the reaction [aluminum lactate results in increased expression of BAX protein]; Quercetin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of BAX protein]; Quercetin inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]; Quercetin inhibits the reaction [cypermethrin results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [cypermethrin results in increased expression of BAX protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BAX protein]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Quercetin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Thioacetamide affects the expression of BAX protein modified form]; Quercetin inhibits the reaction [triptolide affects the expression of BAX protein]; Quercetin inhibits the reaction [Vincristine results in increased expression of BAX mRNA]PMID:19466539 PMID:19794523 PMID:21803128 PMID:21885874 PMID:22524206 PMID:23138875 PMID:23281070 PMID:23907460 PMID:24316378 PMID:26277538 PMID:26476374 PMID:26944603 PMID:27389774 PMID:27525270 PMID:28000380 PMID:30990955 PMID:32034696 PMID:33038355 PMID:33439051 PMID:35876585
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDQuercetin affects the expression of BAX proteinPMID:15975156
Baxaffects foldingISOBAX (Homo sapiens)6480464CTDQuercetin affects the folding of BAX proteinPMID:21165570
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDQuercetin affects the localization of BAX proteinPMID:18455702
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDQuercetin results in decreased expression of BAX proteinPMID:22555976
Baxincreases activityISOBAX (Homo sapiens)6480464CTDQuercetin results in increased activity of BAX proteinPMID:18359480
Baxincreases expressionISOBax (Mus musculus)6480464CTDQuercetin results in increased expression of BAX mRNA; Quercetin results in increased expression of BAX proteinPMID:17039455 PMID:25543474
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDQuercetin metabolite results in increased expression of BAX protein; Quercetin results in increased expression of BAX; Quercetin results in increased expression of BAX mRNA; Quercetin results in increased expression of BAX proteinPMID:14688022 PMID:16049707 PMID:16059641 PMID:16280456 PMID:16898267 PMID:17652743 PMID:20386985 PMID:21632981 PMID:22200874 PMID:22222411 PMID:22431435 PMID:22447039 PMID:22983795 PMID:24535669 PMID:25293876 PMID:25339540 PMID:25830055 PMID:25896339 PMID:26311153 PMID:28811126 PMID:30152185 PMID:30639267 PMID:33070227
Baxincreases response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to QuercetinPMID:18455702 PMID:21138867
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Quercetin inhibits the reaction [4-nitro-3-cresol results in increased expression of BAX protein]; Quercetin inhibits the reaction [4-nitrophenol results in increased expression of BAX protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Quercetin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Quercetin inhibits the reaction [CCL2 protein affects the expression of BAX mRNA]; Quercetin inhibits the reaction [CX3CR1 protein affects the expression of BAX mRNA]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]; Quercetin inhibits the reaction [Okadaic Acid results in increased expression of BAX protein]PMID:20361964 PMID:21337715 PMID:22467373 PMID:23997041 PMID:27050422 PMID:28681665 PMID:34726822
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[BAX protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein; [Quercetin co-treated with Cisplatin] results in increased expression of BAX protein; [Quercetin results in increased susceptibility to Cisplatin] which results in increased expression of BAX protein; AKT1 protein inhibits the reaction [Quercetin results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Quercetin results in increased activity of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Emulsions promotes the reaction [Quercetin inhibits the reaction [Paraquat results in increased expression of BAX mRNA]]; MCL1 protein inhibits the reaction [Quercetin results in increased localization of and results in increased activity of BAX protein]; NFE2L2 protein inhibits the reaction [Quercetin results in increased expression of BAX protein]; Quercetin inhibits the reaction [BCL2L1 protein binds to BAX protein]; Quercetin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Quercetin inhibits the reaction [Isoniazid results in increased expression of BAX protein]; Quercetin inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [squamosamide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; Quercetin promotes the reaction [Arsenic Trioxide results in increased activity of BAX protein]; Quercetin promotes the reaction [TNFSF10 protein affects the localization of BAX protein]; Quercetin promotes the reaction [TNFSF10 protein results in increased expression of BAX protein]; Quercetin results in increased localization of and results in increased activity of BAX proteinPMID:12672908 PMID:16082193 PMID:16619537 PMID:17652743 PMID:17876056 PMID:18359480 PMID:18455702 PMID:20361964 PMID:20386985 PMID:21138867 PMID:21295016 PMID:23711929 PMID:25108166 PMID:25896339 PMID:27132804 PMID:27470402 PMID:31332904 PMID:32527420
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