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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16112
Term: chlorogenic acid
Definition: A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is an intermediate metabolite in the biosynthesis of lignin.
Chemical ID: MESH:D002726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDChlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]PMID:28479099
Baxincreases expressionISOBax (Mus musculus)6480464CTDChlorogenic Acid results in increased expression of BAX mRNA; Chlorogenic Acid results in increased expression of BAX proteinPMID:33058431
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDChlorogenic Acid inhibits the reaction [Aluminum Chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]PMID:25043994 PMID:28623112 PMID:33242462
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