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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDAtrazine affects the expression of BAXPMID:21726175
Baxincreases expressionEXP 6480464CTDAtrazine results in increased expression of BAX mRNA; Atrazine results in increased expression of BAX proteinPMID:26075868 PMID:36282381
Baxmultiple interactionsEXP 6480464CTDCarnitine inhibits the reaction [Atrazine results in increased expression of BAX mRNA]; kolaviron inhibits the reaction [Atrazine affects the expression of BAX]PMID:21726175 PMID:36282381
Baxdecreases expressionISOBax (Mus musculus)6480464CTDAtrazine results in decreased expression of BAX proteinPMID:22515965
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDAtrazine results in decreased expression of BAX mRNA; Atrazine results in decreased expression of BAX proteinPMID:21333729
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in decreased expression of BAX proteinPMID:22515965
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDkolaviron inhibits the reaction [Atrazine results in decreased expression of BAX protein]; kolaviron promotes the reaction [Atrazine results in decreased expression of BAX mRNA]PMID:21333729
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