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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDCatechin analog inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Catechin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; Catechin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]PMID:18611398 PMID:34027802
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCatechin results in increased expression of BAX mRNA; Catechin results in increased expression of BAX proteinPMID:23706674
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA]PMID:21882252
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