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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BAX proteinPMID:34418242
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDMitoTEMPO inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BAX protein]PMID:34418242
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of BAX proteinPMID:15782132 PMID:19540902
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