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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTD1,2-Dimethylhydrazine results in decreased expression of BAX mRNA; 1,2-Dimethylhydrazine results in decreased expression of BAX proteinPMID:29108773 PMID:34627785
Baxincreases expressionEXP 6480464CTD1,2-Dimethylhydrazine results in increased expression of BAX mRNA; 1,2-Dimethylhydrazine results in increased expression of BAX proteinPMID:31925992 PMID:32387197
Baxmultiple interactionsEXP 6480464CTD[1,2-Dimethylhydrazine co-treated with Artesunate] results in increased expression of BAX protein; asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX protein]; Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BAX protein]; piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX mRNA]PMID:29031619 PMID:29108773 PMID:31925992 PMID:34627785
Baxincreases expressionISOBax (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in increased expression of BAX mRNAPMID:22206623
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