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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDcobaltous chloride results in increased expression of BAX proteinPMID:21499890 PMID:28303633 PMID:30596275
Baxmultiple interactionsEXP 6480464CTDrhodioloside inhibits the reaction [cobaltous chloride results in increased expression of BAX protein]PMID:21499890
Baxincreases expressionISOBax (Mus musculus)6480464CTDcobaltous chloride results in increased expression of BAX mRNA; cobaltous chloride results in increased expression of BAX proteinPMID:23251428 PMID:24265542
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of BAX mRNA; cobaltous chloride results in increased expression of BAX proteinPMID:14741615 PMID:18078969
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [cobaltous chloride results in increased expression of BAX mRNA]PMID:24265542
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDcobaltous chloride inhibits the reaction [[Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BAX mRNA]PMID:19714248
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