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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:34727
Term: domoic acid
Definition: An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP).
Chemical ID: MESH:C012301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDdomoic acid results in increased expression of BAX mRNAPMID:18293405
Baxincreases localizationISOBax (Mus musculus)6480464CTDdomoic acid results in increased localization of BAX proteinPMID:19200344
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCarbachol inhibits the reaction [domoic acid results in increased localization of BAX protein]PMID:19200344
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