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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDSodium Fluoride results in increased expression of BAX mRNA; Sodium Fluoride results in increased expression of BAX proteinPMID:18696052 PMID:27871895 PMID:29758312 PMID:35172196 PMID:35413380
Baxmultiple interactionsEXP 6480464CTDHesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]; protocatechuic acid methyl ester inhibits the reaction [Sodium Fluoride results in increased expression of BAX protein]; Sodium Fluoride affects the reaction [Gentamicins affects the expression of BAX mRNA]PMID:26779593 PMID:27871895 PMID:29758312 PMID:35413380
Baxincreases expressionISOBax (Mus musculus)6480464CTDSodium Fluoride results in increased expression of BAX mRNA; Sodium Fluoride results in increased expression of BAX proteinPMID:23578390 PMID:27871895
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of BAX mRNA]; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; [Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of BAX mRNA; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]PMID:27871895 PMID:35714946
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