GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | EXP | | 6480464 | CTD | Lead results in increased expression of BAX protein | PMID:22129743 PMID:29630945 | Bax | multiple interactions | EXP | | 6480464 | CTD | [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein; [lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein; Grape Seed Proanthocyanidins inhibits the reaction [Lead results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Lead results in increased expression of BAX protein]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein] | PMID:22129743 PMID:29630945 PMID:33242459 PMID:36925031 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Lead results in increased expression of BAX protein | PMID:31539617 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | fisetin inhibits the reaction [Lead results in increased expression of BAX protein] | PMID:31539617 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of BAX mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA] | PMID:29115570 PMID:30738203 | | ||||||||||||||||||||||
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