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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]PMID:32007421
Baxaffects localizationISOBax (Mus musculus)6480464CTDTretinoin affects the localization of BAX proteinPMID:16712891
Baxincreases cleavageISOBAX (Homo sapiens)6480464CTDTretinoin results in increased cleavage of BAX proteinPMID:16242776
Baxincreases expressionISOBax (Mus musculus)6480464CTDTretinoin results in increased expression of BAX proteinPMID:21626648
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDTretinoin results in increased expression of BAX; Tretinoin results in increased expression of BAX mRNA; Tretinoin results in increased expression of BAX proteinPMID:14592536 PMID:14646600 PMID:15254726 PMID:16109544 PMID:16109552 PMID:16196285 PMID:16411021 PMID:16909596 PMID:21159206 PMID:9342185
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with IFNG protein] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; [Tretinoin co-treated with Zoledronic Acid] results in increased expression of BAX protein; leptomycin B inhibits the reaction [Tretinoin results in increased expression of BAX protein]; leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein]; TGFB1 protein inhibits the reaction [Tretinoin results in increased cleavage of BAX protein]; Tretinoin inhibits the reaction [perfluorooctanoic acid results in increased expression of BAX protein]PMID:10965999 PMID:14592536 PMID:16242776 PMID:17960384 PMID:20349282 PMID:32971237 PMID:9649124
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