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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:101896480464CTDARNT affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA], ARNT promotes the reaction [beta-Naphthoflavone results in decreased abundance of Lactic Acid], beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein], beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein], kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]], kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]

PMID:17012224, PMID:21849270
multiple interactionsISORGD:7327396480464CTDAHR gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]], beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein], beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]

PMID:19901195, PMID:21127131, PMID:24486526
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.