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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arntaffects expressionEXP 6480464CTDEstradiol affects the expression of ARNT mRNAPMID:24777823
Arntdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of ARNT mRNAPMID:22127542
Arntmultiple interactionsEXP 6480464CTD11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in decreased expression of ARNT mRNA]; [Progesterone co-treated with Estradiol] affects the expression of ARNT mRNAPMID:22127542 PMID:24777823
Arntaffects response to substanceISOARNT (Homo sapiens)6480464CTDARNT protein affects the susceptibility to EstradiolPMID:22235307
Arntdecreases expressionISOARNT (Homo sapiens)6480464CTDEstradiol results in decreased expression of ARNT mRNAPMID:31614463
Arntmultiple interactionsISOArnt (Mus musculus)6480464CTDEstradiol promotes the reaction [ARNT protein binds to FOS promoter]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]]PMID:17991765
Arntmultiple interactionsISOARNT (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]; AHR gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]]; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]; ARNT protein affects the reaction [Estradiol results in increased expression of CTSD mRNA]; ARNT protein affects the reaction [Estradiol results in increased expression of TFF1 mRNA]; Estradiol promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Estradiol promotes the reaction [ARNT protein binds to HSPB8 promoter]; Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]PMID:11165043 PMID:16675542 PMID:22071320 PMID:22235307 PMID:24299737
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