GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Areg | affects response to substance | ISO | AREG (Homo sapiens) | 6480464 | CTD | AREG protein affects the susceptibility to gefitinib | PMID:18980991 | Areg | decreases response to substance | ISO | AREG (Homo sapiens) | 6480464 | CTD | AREG protein results in decreased susceptibility to gefitinib | PMID:15496427 PMID:16230376 | Areg | multiple interactions | ISO | AREG (Homo sapiens) | 6480464 | CTD | Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein]; Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of AREG mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of AREG mRNA] | PMID:15723263 PMID:21258428 | |
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