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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTDDexamethasone binds to AR proteinPMID:14565775
Armultiple interactionsEXP 6480464CTD[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]; bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]PMID:20032058
Araffects activityISOAR (Homo sapiens)6480464CTDDexamethasone affects the activity of AR proteinPMID:15084347
Araffects bindingISOAR (Homo sapiens)6480464CTDDexamethasone binds to AR protein mutant formPMID:11956172
Ardecreases expressionISOAR (Homo sapiens)6480464CTDDexamethasone results in decreased expression of AR mRNAPMID:19681914
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Dexamethasone inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:18324785 PMID:28803809
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