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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:2564
Term: aldrin
Definition: An organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with norbornadiene. A proinsecticide (by epoxidation of the non-chlorinated double bond to give dieldrin), it was widely used as an insecticide before being banned in the 1970s as a persistent organic pollutant.
Chemical ID: MESH:D000452
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTDAldrin binds to AR proteinPMID:14565775
Armultiple interactionsISOAR (Homo sapiens)6480464CTDAldrin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Aldrin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]PMID:21295777 PMID:26022396
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