GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | App | decreases methylation | ISO | App (Mus musculus) | 6480464 | CTD | S-Adenosylhomocysteine results in decreased methylation of APP promoter | PMID:19635394 | App | increases expression | ISO | App (Mus musculus) | 6480464 | CTD | S-Adenosylhomocysteine results in increased expression of APP protein | PMID:22064374 | App | multiple interactions | ISO | App (Mus musculus) | 6480464 | CTD | Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein | PMID:19635394 | | ||||||||||||||||||||||
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