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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2138
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:42839
Term: 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine
Definition: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.
Chemical ID: MESH:D011692
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoeaffects expressionEXP 6480464CTDPuromycin Aminonucleoside affects the expression of APOE mRNAPMID:8413767
Apoeincreases expressionEXP 6480464CTDPuromycin Aminonucleoside results in increased expression of APOE proteinPMID:7442475
Apoedecreases response to substanceISOApoe (Mus musculus)6480464CTDAPOE protein results in decreased susceptibility to Puromycin AminonucleosidePMID:12472773
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