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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apc
Name: APC regulator of WNT signaling pathway
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apcincreases mutagenesisEXP 6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC genePMID:11181456 PMID:14507667 PMID:7846077 PMID:8608549 PMID:9202738
Apcmultiple interactionsEXP 6480464CTD[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased mutagenesis of APC genePMID:11756241
Apcaffects response to substanceISOApc (Mus musculus)6480464CTDAPC protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:11323404 PMID:9163695
Apcincreases mutagenesisISOApc (Mus musculus)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC genePMID:11420398 PMID:12034317 PMID:14706516
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