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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2118
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Anxa1
Name: annexin A1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Anxa1decreases response to substanceEXP 6480464CTDANXA1 protein results in decreased susceptibility to LipopolysaccharidesPMID:16835395
Anxa1multiple interactionsISOAnxa1 (Mus musculus)6480464CTDANXA1 protein affects the reaction [Lipopolysaccharides affects the secretion of IL6 protein]; ANXA1 protein affects the reaction [Lipopolysaccharides affects the secretion of TNF protein]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]PMID:16633358 PMID:21777521
Anxa1multiple interactionsISOANXA1 (Homo sapiens)6480464CTDANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:21777521
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