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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2100
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
Acc ID: CHEBI:6432
Term: levamisole
Definition: A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.
Chemical ID: MESH:D007978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alpldecreases activityISOAlpl (Mus musculus)6480464CTDLevamisole results in decreased activity of ALPL proteinPMID:27466191
Alplincreases response to substanceISOAlpl (Mus musculus)6480464CTDALPL gene mutant form results in increased susceptibility to LevamisolePMID:27466191
Alplmultiple interactionsISOALPL (Homo sapiens)6480464CTDLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]PMID:18500657
Alplmultiple interactionsISOAlpl (Mus musculus)6480464CTD[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNAPMID:27466191
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