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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:43645
Term: indirubin-3'-monoxime
Definition: A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
Chemical ID: MESH:C474021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects bindingISOAhr (Mus musculus)6480464CTDindirubin-3'-monoxime binds to AHR proteinPMID:15001395
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDAHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]PMID:21948866
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDindirubin-3'-monoxime binds to and results in increased activity of AHR proteinPMID:15001395
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